Due to the presentation of active sites under ideal conditions NaCoMag Coatings have the following product advantages:
- Drastically increased binding and elution capabilities
- High batch to batch and test to test reproducibility
- Ability to stabilize domains prone to easy denaturation
4 Protein A beads from leading magnetic bead providers were compared to non-protein A beads from the same providers with otherwise exactly the same bead properties, but coated with NaCoMag protein A coating. In all cases the performance increase was significant.
In addition, due to the nature of the self-assembling protein cushion, NaCoMag Coatings:
- Are highly stable under adverse physicochemical conditions
- Show exceptionally low unspecific binding
Unspecific binding test with NaCoMag protein A beads: (1) IgG, (2) Serum, (3) Serum spiked with IgG, (4) IgG bound to NaCoMag Protein A beads after removal from spiked serum, (5) IgG eluted from NaCoMag Protein A beads